Lack of homologous protection against Campylobacter jejuni CG8421 in a human challenge model.

ABSTRACT:

Background

Campylobacter jejuni is a common cause of diarrhea and is associated with serious postinfectious sequelae. Although symptomatic and asymptomatic infections are recognized, protective immunity is not well understood. Previous data suggests that interferon γ (IFN-γ) may be associated with protection. To better define the clinical and immunologic development of protective immunity to C. jejuni, we assessed the ability of an initial infection to prevent clinical illness after a second experimental infection.

Methods

Subjects with no clinical or immunologic evidence of prior infection with C. jejuni received an initial challenge with C. jejuni CG8421 with rechallenge 3 months later. The primary endpoint was campylobacteriosis, as defined by diarrhea and/or systemic sig

SUBMITTER: Kirkpatrick BD 

PROVIDER: S-EPMC3888245 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature