Serotype-specific effect of influenza on adult invasive pneumococcal pneumonia.

ABSTRACT:

Background

 Influenza affects host susceptibility to pneumococcus. We sought to evaluate whether this relationship varies by pneumococcal serotype using a large epidemiological database covering 3 decades.

Methods

 Weekly rates of invasive pneumococcal pneumonia (IPP) were obtained from the Danish National Laboratory Surveillance System, and influenza-like illness (ILI) data were collected from Danish sentinel surveillance, Statens Serum Institut, 1977-2007. We fit Poisson regression models for each age and comorbidity group, with predictors for seasonality and secular changes, ILI activity, and serotype.

Results

 Among individuals with low levels of comorbidities, influenza had the largest impact on IPP incidence among low-invasiveness serotypes (influenza attributab

SUBMITTER: Weinberger DM 

PROVIDER: S-EPMC3888281 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature