Regional ion channel gene expression heterogeneity and ventricular fibrillation dynamics in human hearts.

ABSTRACT:

Rationale

Structural differences between ventricular regions may not be the sole determinant of local ventricular fibrillation (VF) dynamics and molecular remodeling may play a role.

Objectives

To define regional ion channel expression in myopathic hearts compared to normal hearts, and correlate expression to regional VF dynamics.

Methods and results

High throughput real-time RT-PCR was used to quantify the expression patterns of 84 ion-channel, calcium cycling, connexin and related gene transcripts from sites in the LV, septum, and RV in 8 patients undergoing transplantation. An additional eight non-diseased donor human hearts served as controls. To relate local ion channel expression change to VF dynamics localized VF mapping was performed on the explanted myopathic

SUBMITTER: Sivagangabalan G 

PROVIDER: S-EPMC3888386 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature