MR-less surface-based amyloid assessment based on 11C PiB PET.

ABSTRACT:

Background

β-amyloid (Aβ) plaques in brain's grey matter (GM) are one of the pathological hallmarks of Alzheimer's disease (AD), and can be imaged in vivo using Positron Emission Tomography (PET) with (11)C or (18)F radiotracers. Estimating Aβ burden in cortical GM has been shown to improve diagnosis and monitoring of AD. However, lacking structural information in PET images requires such assessments to be performed with anatomical MRI scans, which may not be available at different clinical settings or being contraindicated for particular reasons. This study aimed to develop an MR-less Aβ imaging quantification method that requires only PET images for reliable Aβ burden estimations.

Materials and methods

The proposed method has been developed using a multi-atlas based approa

SUBMITTER: Zhou L 

PROVIDER: S-EPMC3888418 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature