Serum dioxin concentrations and bone density and structure in the Seveso Women's Health Study.

ABSTRACT:

Background

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a widespread environmental contaminant, is a known endocrine disruptor. In animal studies, TCDD exposure impairs bone metabolism and increases fragility. To our knowledge, no epidemiologic studies have examined this association.

Objectives

On 10 July 1976, a chemical explosion in Seveso, Italy, resulted in the highest known residential exposure to TCDD. In 1996, we initiated the Seveso Women's Health Study, a retrospective cohort study of the health of the women. In 2008, we followed up the cohort. Here, we evaluated the association between TCDD exposure and bone structure and geometry in adulthood, and considered whether timing of TCDD exposure before achievement of peak bone mass (assumed to occur 2 years after onset o

SUBMITTER: Eskenazi B 

PROVIDER: S-EPMC3888571 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature