Classification of posterior polymorphous corneal dystrophy as a corneal ectatic disorder following confirmation of associated significant corneal steepening.

ABSTRACT:

Importance

The identification of steep corneal curvatures in a significant percentage of patients with posterior polymorphous corneal dystrophy (PPCD) confirms this previously reported association and suggests a role for the ZEB1 protein in keratocyte function.

Objective

To determine whether PPCD is characterized by significant corneal steepening.

Design, setting, and participants

Cross-sectional study at university-based and private ophthalmology practices of 38 individuals (27 affected and 11 unaffected) from 23 families with PPCD.

Exposure

Slitlamp examination and corneal topographic imaging were performed for individuals with PPCD and unaffected family members. Saliva or blood samples were obtained from each individual for DNA isolation and ZEB1 sequencing.

SUBMITTER: Aldave AJ 

PROVIDER: S-EPMC3888803 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature