The influence of tuberculosis treatment on efavirenz clearance in patients co-infected with HIV and tuberculosis.

ABSTRACT:

Purpose

Drug interactions are of concern when treating patients co-infected with human immunodeficiency virus (HIV) and tuberculosis. Concomitant use of efavirenz (EFV) with the enzyme inducer rifampicin might be expected to increase EFV clearance. We investigated the influence of concomitant tuberculosis treatment on the plasma clearance of EFV.

Methods

Fifty-eight patients were randomized to receive their EFV-containing antiretroviral therapy either during or after tuberculosis treatment. Steady-state EFV plasma concentrations (n = 209 samples) were measured, 83 in the presence of rifampicin. Data were analyzed using a non-linear mixed effects model, and the model was evaluated using non-parametric bootstrap and visual predictive checks.

Results

The patients had a m

SUBMITTER: Gengiah TN 

PROVIDER: S-EPMC3888951 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature