Prostaglandin D₂ pathway upregulation: relation to asthma severity, control, and TH2 inflammation.

ABSTRACT:

Background

Bronchoalveolar lavage (BAL) fluid prostaglandin D₂(PGD₂) levels are increased in patients with severe, poorly controlled asthma in association with epithelial mast cells (MCs). PGD₂, which is generated by hematopoietic prostaglandin D synthase (HPGDS), acts on 3 G protein-coupled receptors, including chemoattractant receptor-homologous molecule expressed on TH2 lymphocytes (CRTH2) and PGD₂ receptor 1 (DP1). However, much remains to be understood regarding the presence and activation of these pathway elements in asthmatic patients.

Objective

We sought to compare the expression and activation of PGD₂ pathway elements in bronchoscopically obtained samples from healthy control subjects and asthmatic patients across a range of disease severity and control, as well as

SUBMITTER: Fajt ML 

PROVIDER: S-EPMC3889167 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature