Template-constrained cyclic sulfopeptide HIV-1 entry inhibitors.

ABSTRACT: Template-constrained cyclic sulfopeptides that inhibit HIV-1 entry were rationally designed based on a loop from monoclonal antibody (mAb) 412d. A focused set of sulfopeptides was synthesized using Fmoc-Tyr(SO3DCV)-OH (DCV = 2,2-dichlorovinyl). Three cyclic sulfopeptides that inhibit entry of HIV-1 and complement the activity of known CCR5 antagonists were identified.

SUBMITTER: Rudick JG 

PROVIDER: S-EPMC3889485 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature