Importance of hematocrit for a tacrolimus target concentration strategy.

ABSTRACT:

Purpose

To identify patient characteristics that influence tacrolimus individual dose requirement in kidney transplant recipients.

Methods

Data on forty-four 12-h pharmacokinetic profiles from 29 patients and trough concentrations in 44 patients measured during the first 70 days after transplantation (1,546 tacrolimus whole blood concentrations) were analyzed. Population pharmacokinetic modeling was performed using NONMEM 7.2®.

Results

Standardization of tacrolimus whole blood concentrations to a hematocrit value of 45 % improved the model fit significantly (p<0.001). Fat-free mass was the best body size metric to predict tacrolimus clearance and volume of distribution. Bioavailability was 49 % lower in expressers of cytochrome P450 3A5 (CYP3A5) than in CYP3A5 nonexpr

SUBMITTER: Storset E 

PROVIDER: S-EPMC3889505 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature