Synergistic antibiotic combination powders of colistin and rifampicin provide high aerosolization efficiency and moisture protection.

ABSTRACT: For many respiratory infections caused by multidrug-resistant Gram-negative bacteria, colistin is the only effective antibiotic despite its nephrotoxicity. A novel inhaled combination formulation of colistin with a synergistic antimicrobial component of rifampicin was prepared via co-spray drying, aiming to deliver the drug directly to the respiratory tract and minimize drug resistance and adverse effects. Synergistic antibacterial activity against Acinetobacter baumannii was demonstrated for the combination formulation with high emitted doses (96%) and fine particle fraction total (FPFtotal; 92%). Storage of the spray-dried colistin alone formulation in the elevated relative humidity (RH) of 75% resulted in a substantial deterioration in the aerosolization performance because the amorphou

SUBMITTER: Zhou QT 

PROVIDER: S-EPMC3889531 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature