Thalamic physiology of intentional essential tremor is more like cerebellar tremor than postural essential tremor.

ABSTRACT: The neuronal physiological correlates of clinical heterogeneity in human essential tremor are unknown. We now test the hypothesis that thalamic neuronal and EMG activities during intention essential tremor are similar to those of the intention tremor which is characteristic of cerebellar lesions. Thalamic neuronal firing was studied in a cerebellar relay nucleus (ventral intermediate, Vim) and in a pallidal relay nucleus (ventral oral posterior, Vop) during stereotactic surgery for the treatment of tremor. Nine patients with essential tremor were divided clinically into two categories: one with a substantial component of tremor with intention (termed intention ET) and the other without (postural ET). These types of essential tremor were compared with patients having intention tremor plus o

SUBMITTER: Zakaria R 

PROVIDER: S-EPMC3889719 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature