Urine proteomes of healthy aging humans reveal extracellular matrix (ECM) alterations and immune system dysfunction.

ABSTRACT: Aging is a complex physiological process that poses considerable conundrums to rapidly aging societies. For example, the risk of dying from cardiovascular diseases and/or cancer steadily declines for people after their 60s, and other causes of death predominate for seniors older than 80 years of age. Thus, physiological aging presents numerous unanswered questions, particularly with regard to changing metabolic patterns. Urine proteomics analysis is becoming a non-invasive and reproducible diagnostic method. We investigated the urine proteomes in healthy elderly people to determine which metabolic processes were weakened or strengthened in aging humans. Urine samples from 37 healthy volunteers aged 19-90 years (19 men, 18 women) were analyzed for protein expression by liquid chromatography

SUBMITTER: Bakun M 

PROVIDER: S-EPMC3889913 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature