Plasma concentrations of soluble IL-2 receptor α (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients.

ABSTRACT:

Aims/hypothesis

Type 1 diabetes is a common autoimmune disease that has genetic and environmental determinants. Variations within the IL2 and IL2RA (also known as CD25) gene regions are associated with disease risk, and variation in expression or function of these proteins is likely to be causal. We aimed to investigate if circulating concentrations of the soluble form of CD25, sCD25, an established marker of immune activation and inflammation, were increased in individuals with type 1 diabetes and if this was associated with the concentration of C-peptide, a measure of insulin production that reflects the degree of autoimmune destruction of the insulin-producing beta cells.

Methods

We used immunoassays to measure sCD25 and C-peptide in peripheral blood plasma from patient a

SUBMITTER: Downes K 

PROVIDER: S-EPMC3890035 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature