Adhesion molecules, endothelin-1 and lung function in seven population-based cohorts.

ABSTRACT:

Context

Endothelial function is abnormal in chronic obstructive pulmonary disease (COPD); whether endothelial dysfunction causes COPD is unknown.

Objective

Test associations of endothelial biomarkers with FEV1 using instrumental variables.

Methods

Among 26 907 participants with spirometry, ICAM-1, P-selectin, E-selectin and endothelin-1 were measured in subsets.

Results

ICAM-1 and P-selectin were inversely associated with FEV1 among European-Americans (-29 mL and -34 mL per standard deviation of log-transformed biomarker, p < 0.001), as was endothelin-1 among African-Americans (-22 mL, p = 0.008). Genetically-estimated ICAM-1 and P-selectin were not significantly associated with FEV1. The instrumental variable for endothelin-1 was non-informative.

Conclusion

SUBMITTER: Oelsner EC 

PROVIDER: S-EPMC3890095 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature