Diagnostic accuracy of five serologic tests for Strongyloides stercoralis infection.

ABSTRACT:

Background

The diagnosis of Strongyloides stercoralis (S. stercoralis) infection is hampered by the suboptimal sensitivity of fecal-based tests. Serological methods are believed to be more sensitive, although assessing their accuracy is difficult because of the lack of sensitivity of a fecal-based reference ("gold") standard.

Methods

The sensitivity and specificity of 5 serologic tests for S. stercoralis (in-house IFAT, NIE-ELISA and NIE-LIPS and the commercially available Bordier-ELISA and IVD-ELISA) were assessed on 399 cryopreserved serum samples. Accuracy was measured using fecal results as the primary reference standard, but also using a composite reference standard (based on a combination of tests).

Results

According to the latter standard, the most sensitive te

SUBMITTER: Bisoffi Z 

PROVIDER: S-EPMC3890421 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature