Transcriptomic and genomic evidence for Streptococcus agalactiae adaptation to the bovine environment.

ABSTRACT:

Background

Streptococcus agalactiae is a major cause of bovine mastitis, which is the dominant health disorder affecting milk production within the dairy industry and is responsible for substantial financial losses to the industry worldwide. However, there is considerable evidence for host adaptation (ecotypes) within S. agalactiae, with both bovine and human sourced isolates showing a high degree of distinctiveness, suggesting differing ability to cause mastitis. Here, we (i) generate RNAseq data from three S. agalactiae isolates (two putative bovine adapted and one human) and (ii) compare publicly available whole genome shotgun sequence data from an additional 202 isolates, obtained from six host species, to elucidate possible genetic factors/adaptations likely important for S. a

SUBMITTER: Richards VP 

PROVIDER: S-EPMC3890567 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature