Diversity and history of the long-chain acyl-CoA synthetase (Acsl) gene family in vertebrates.

ABSTRACT:

Background

Fatty acids, a considerable fraction of lipid molecules, participate in fundamental physiological processes. They undergo activation into their corresponding CoA esters for oxidation or esterification into complex lipids (e.g. triglycerides, phospholipids and cholesterol esters), a process that is carried out by acyl-CoA synthases (ACS). Here we analyze the evolution of the gene family encoding for the long-chain acyl-CoA synthetases (Acsl) in vertebrates.

Results

By means of phylogenetics and comparative genomics we show that genome duplications (2R) generated the diversity of Acsl genes in extant vertebrate lineages. In the vertebrate ancestor two separate genes originated the current Acsl1/5/6 and the Acsl3/4 gene families, and the extra gene duplicates in tele

SUBMITTER: Lopes-Marques M 

PROVIDER: S-EPMC3890633 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature