Discovery of MLL1 binding units, their localization to CpG Islands, and their potential function in mitotic chromatin.

ABSTRACT:

Background

Mixed Lineage Leukemia 1 (MLL1) is a mammalian ortholog of the Drosophila Trithorax. In Drosophila, Trithorax complexes transmit the memory of active genes to daughter cells through interactions with Trithorax Response Elements (TREs). However, despite their functional importance, nothing is known about sequence features that may act as TREs in mammalian genomic DNA.

Results

By analyzing results of reported DNA binding assays, we identified several CpG rich motifs as potential MLL1 binding units (defined as morphemes). We find that these morphemes are dispersed within a relatively large collection of human promoter sequences and appear densely packed near transcription start sites of protein-coding genes. Genome wide analyses localized frequent morpheme occurrence

SUBMITTER: Bina M 

PROVIDER: S-EPMC3890651 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature