Transcriptional fine-tuning of microRNA-223 levels directs lineage choice of human hematopoietic progenitors.

ABSTRACT: MicroRNAs (miRNAs) regulate cell proliferation, differentiation and death during development and postnatal life. The expression level of mature miRNAs results from complex molecular mechanisms, including the transcriptional regulation of their genes. MiR-223 is a hematopoietic-specific miRNA participating in regulatory signaling networks involving lineage-specific transcription factors (TFs). However, the transcriptional mechanisms governing its expression levels and its functional role in lineage fate decision of human hematopoietic progenitors (HPCs) have not yet been clarified. We found that in CD34(+)HPCs undergoing unilineage differentiation/maturation, miR-223 is upregulated more than 10-fold during granulopoiesis, 3-fold during monocytopoiesis and maintained at low levels during ery

SUBMITTER: Vian L 

PROVIDER: S-EPMC3890951 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature