Use of high-dose erythropoietin for repair after injury: A comparison of outcomes in heart and kidney.

ABSTRACT:

Context

There is a need to define the exact benefits and contraindications of use of high-dose recombinant human erythropoietin (EPO) for its non-hematopoietic function as a cytokine that enhances tissue repair after injury. This review compares the outcomes from use of EPO in the injured heart and kidney, two organs that are thought, traditionally, to have intrinsically-different repair mechanisms.

Evidence acquisitions

Directory of Open Access Journals (DOAJ), Google Scholar, Pubmed (NLM), LISTA (EBSCO) and Web of Science have been searched.

Results

Ongoing work by us on EPO protection of ischemia-reperfusion-injured kidneys indicated, first, that EPO acutely enhanced kidney repair via anti-apoptotic, pro-regenerative mechanisms, and second, that EPO may promote chr

SUBMITTER: Gobe GC 

PROVIDER: S-EPMC3891135 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature