Dataset Information

Cholecystectomy and clinical presentations of gastroparesis.

ABSTRACT:

Background

Many patients with gastroparesis have had their gallbladders removed.

Aim

To determine if clinical presentations of patients with gastroparesis differ in those with prior cholecystectomy compared to patients who have not had their gallbladder removed.

Methods

Gastroparetic patients were prospectively enrolled in the NIDDK Gastroparesis Registry. Detailed history and physical examinations were performed; patients filled out questionnaires including patient assessment of GI symptoms.

Results

Of 391 subjects with diabetic or idiopathic gastroparesis (IG), 142 (36 %) had a prior cholecystectomy at the time of enrollment. Patients with prior cholecystectomy were more often female, older, married, and overweight or obese. Cholecystectomy had been performed in 27/59 (46 %) of T2DM compared to 19/78 (24 %) T1DM and 96/254 IG (38 %) (p = 0.03). Patients with cholecystectomy had more comorbidities, particularly chronic fatigue syndrome, fibromyalgia, depression, and anxiety. Postcholecystectomy gastroparesis patients had increased health care utilization, and had a worse quality of life. Independent characteristics associated with prior cholecystectomy included insidious onset (OR = 2.06; p = 0.01), more comorbidities (OR = 1.26; p < 0.001), less severe gastric retention (OR(severe) = 0.68; overall p = 0.03) and more severe symptoms of retching (OR = 1.19; p = 0.02) and upper abdominal pain (OR = 1.21; p = 0.02), less severe constipation symptoms (OR = 0.84; p = 0.02), and not classified as having irritable bowel syndrome (OR = 0.51; p = 0.02). Etiology was not independently associated with a prior cholecystectomy.

Conclusions

Symptom profiles in patients with and without cholecystectomy differ: postcholecystectomy gastroparesis patients had more severe upper abdominal pain and retching and less severe constipation. These data suggest that prior cholecystectomy is associated with selected manifestations of gastroparesis.

SUBMITTER: Parkman HP

PROVIDER: S-EPMC3891205 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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Publications

Cholecystectomy and clinical presentations of gastroparesis.

Parkman Henry P HP Yates Katherine K Hasler William L WL Nguyen Linda L Pasricha Pankaj J PJ Snape William J WJ Farrugia Gianrico G Koch Kenneth L KL Calles Jorge J Abell Thomas L TL Sarosiek Irene I McCallum Richard W RW Lee Linda L Unalp-Arida Aynur A Tonascia James J Hamilton Frank F

Digestive diseases and sciences 20130302 4

<h4>Background</h4>Many patients with gastroparesis have had their gallbladders removed.<h4>Aim</h4>To determine if clinical presentations of patients with gastroparesis differ in those with prior cholecystectomy compared to patients who have not had their gallbladder removed.<h4>Methods</h4>Gastroparetic patients were prospectively enrolled in the NIDDK Gastroparesis Registry. Detailed history and physical examinations were performed; patients filled out questionnaires including patient assessm ...[more]

PMID: 23456496

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Dataset Information

Cholecystectomy and clinical presentations of gastroparesis.

Background

Aim

Methods

Results

Conclusions

Publications

Cholecystectomy and clinical presentations of gastroparesis.

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