Towards clinically translatable NIR fluorescence molecular guidance for colonoscopy.

ABSTRACT: White-light surveillance colonoscopy is the standard of care for the detection and removal of premalignant lesions to prevent colorectal cancer, and the main screening recommendation following treatment for recurrence detection. However, it lacks sufficient diagnostic yield, exhibits unacceptable adenoma miss-rates and is not capable of revealing functional and morphological information of the detected lesions. Fluorescence molecular guidance in the near-infrared (NIR) is expected to have outstanding relevance regarding early lesion detection and heterogeneity characterization within and among lesions in these interventional procedures. Thereby, superficial and sub-surface tissue biomarkers can be optimally visualized due to a minimization of tissue attenuation and autofluorescence by comp

SUBMITTER: Garcia-Allende PB 

PROVIDER: S-EPMC3891347 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature