Coordinate H3K9 and DNA methylation silencing of ZNFs in toxicant-induced malignant transformation.

ABSTRACT: Genome-wide disruption of the epigenetic code is a hallmark of malignancy that encompasses many distinct, highly interactive modifications. Delineating the aberrant epigenome produced during toxicant-mediated malignant transformation will help identify the underlying epigenetic drivers of environmental toxicant-induced carcinogenesis. Gene promoter DNA methylation and gene expression profiling of arsenite-transformed prostate epithelial cells showed a negative correlation between gene expression changes and DNA methylation changes; however, less than 10% of the genes with increased promoter methylation were downregulated. Studies described herein confirm that a majority of the DNA hypermethylation events occur at H3K27me3 marked genes that were already transcriptionally repressed. In contr

SUBMITTER: Severson PL 

PROVIDER: S-EPMC3891689 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature