A plant-produced H1N1 trimeric hemagglutinin protects mice from a lethal influenza virus challenge.

ABSTRACT: The increased worldwide awareness of seasonal and pandemic influenza, including pandemic H1N1 virus, has stimulated interest in the development of economic platforms for rapid, large-scale production of safe and effective subunit vaccines. In recent years, plants have demonstrated their utility as such a platform and have been used to produce vaccine antigens against various infectious diseases. Previously, we have produced in our transient plant expression system a recombinant monomeric hemagglutinin (HA) protein (HAC1) derived from A/California/04/09 (H1N1) strain of influenza virus and demonstrated its immunogenicity and safety in animal models and human volunteers. In the current study, to mimic the authentic HA structure presented on the virus surface and to improve stability and immu

SUBMITTER: Shoji Y 

PROVIDER: S-EPMC3891711 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature