Intravascular administration of mannitol for acute kidney injury prevention: a systematic review and meta-analysis.

ABSTRACT:

Background

The effects of mannitol administration on acute kidney injury (AKI) prevention remain uncertain, as the results from clinical studies were conflicting. Due to the lack of strong evidence, the KDIGO Guideline for AKI did not propose completely evidence-based recommendations on this issue.

Methods

We searched PubMed, EMBASE, clinicaltrials.gov and Cochrane Controlled Trials Register. Randomized controlled trials on adult patients at increased risk of AKI were considered on the condition that they compared the effects of intravascular administration of mannitol plus expansion of intravascular volume with expansion of intravascular volume alone. We calculated pooled risk ratios, numbers needed to treat and mean differences with 95% confidence intervals for dichotomous

SUBMITTER: Yang B 

PROVIDER: S-EPMC3891750 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature