High prevalence of antibiotic-resistant bacterial infections among patients with cirrhosis at a US liver center.

ABSTRACT:

Background & aims

There are limited data on the prevalence or predictors of antibiotic-resistant bacterial infections (AR-BI) in hospitalized patients with cirrhosis in North America. Exposure to systemic antibiotics is a risk factor for AR-BI; however, little is known about the effects of the increasingly used oral nonabsorbed antibiotics.

Methods

We analyzed data from patients with cirrhosis and bacterial infections hospitalized in a liver unit at a US hospital between July 2009 and November 2010. Multivariate logistic regression was used to determine predictors of AR-BI. Data were analyzed on the first bacterial infection of each patient (n = 115), and a sensitivity analysis was performed on all infectious episodes per patient (n = 169).

Results

Thirty percent of i

SUBMITTER: Tandon P 

PROVIDER: S-EPMC3891826 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature