Detection of breast cancer with addition of annual screening ultrasound or a single screening MRI to mammography in women with elevated breast cancer risk.

ABSTRACT:

Context

Annual ultrasound screening may detect small, node-negative breast cancers that are not seen on mammography. Magnetic resonance imaging (MRI) may reveal additional breast cancers missed by both mammography and ultrasound screening.

Objective

To determine supplemental cancer detection yield of ultrasound and MRI in women at elevated risk for breast cancer.

Design, setting, and participants

From April 2004-February 2006, 2809 women at 21 sites with elevated cancer risk and dense breasts consented to 3 annual independent screens with mammography and ultrasound in randomized order. After 3 rounds of both screenings, 612 of 703 women who chose to undergo an MRI had complete data. The reference standard was defined as a combination of pathology (biopsy results that

SUBMITTER: Berg WA 

PROVIDER: S-EPMC3891886 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature