Global dynamic optimization approach to predict activation in metabolic pathways.

ABSTRACT:

Background

During the last decade, a number of authors have shown that the genetic regulation of metabolic networks may follow optimality principles. Optimal control theory has been successfully used to compute optimal enzyme profiles considering simple metabolic pathways. However, applying this optimal control framework to more general networks (e.g. branched networks, or networks incorporating enzyme production dynamics) yields problems that are analytically intractable and/or numerically very challenging. Further, these previous studies have only considered a single-objective framework.

Results

In this work we consider a more general multi-objective formulation and we present solutions based on recent developments in global dynamic optimization techniques. We illustrate t

SUBMITTER: de Hijas-Liste GM 

PROVIDER: S-EPMC3892042 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature