The investigation of 125I seed implantation as a salvage modality for unresectable pancreatic carcinoma.

ABSTRACT:

Background

To assess the efficacy of intraoperative ultrasound-guided implantation of 125I seeds for the treatment of unresectable pancreatic carcinoma, and analyze the associated prognostic factors.

Methods

Twenty-eight patients with pancreatic carcinoma who underwent laparotomy and were considered to have unresectable tumors were included in this study. Nine patients were pathologically diagnosed with Stage II disease, and nineteen patients with Stage III disease. Twenty-eight patients received intraoperative ultrasound-guided 125I seed implantation and received a D90 (at least 90% of the tumor volume received the reference dose) ranging from 60 to 163 Gy, with a median of 120 Gy. Seven patients received an additional 35-50 Gy external beam radiotherapy after seed implanta

SUBMITTER: Wang H 

PROVIDER: S-EPMC3892087 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature