Systematic review and meta-analysis of fibrin sealants for patients undergoing pancreatic resection.

ABSTRACT:

Introduction

Post-operative pancreatic fistula (POPF) is a common complication after partial pancreatic resection, and is associated with increased rates of sepsis, mortality and costs. The role of fibrin sealants in decreasing the risk of POPF remains debatable. The aim of this study was to evaluate the literature regarding the effectiveness of fibrin sealants in pancreatic surgery.

Methods

A comprehensive database search was conducted. Only randomized controlled trials comparing fibrin sealants with standard care were included. A meta-analysis regarding POPF, intra-abdominal collections, post-operative haemorrhage, pancreatitis and wound infections was performed according to the recommendations of the Cochrane collaboration.

Results

Seven studies were included, acco

SUBMITTER: Orci LA 

PROVIDER: S-EPMC3892308 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature