Expression profiling of cervical cancers in Indian women at different stages to identify gene signatures during progression of the disease.

ABSTRACT: Cervical cancer is the second most common cancer among women worldwide, with developing countries accounting for >80% of the disease burden. Although in the West, active screening has been instrumental in reducing the incidence of cervical cancer, disease management is hampered due to lack of biomarkers for disease progression and defined therapeutic targets. Here we carried out gene expression profiling of 29 cervical cancer tissues from Indian women, spanning International Federation of Gynaecology and Obstetrics (FIGO) stages of the disease from early lesion (IA and IIA) to progressive stages (IIB and IIIA-B), and identified distinct gene expression signatures. Overall, metabolic pathways, pathways in cancer and signaling pathways were found to be significantly upregulated, while focal

SUBMITTER: Thomas A 

PROVIDER: S-EPMC3892388 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature