Symptom burden and splenomegaly in patients with myelofibrosis in the United States: a retrospective medical record review.

ABSTRACT: Myelofibrosis (MF) is a clonal hematopoietic malignancy characterized by constitutional and localized symptoms, progressive splenomegaly, bone marrow fibrosis, and cytopenias. Although MF is well studied, few studies exist regarding its symptomatic burden in routine clinical practice. This study aimed to characterize symptoms and other clinical features of MF among patients in the United States. We conducted a retrospective medical record review of adult patients with an MF diagnosis between 1 January 2005 and 31 March 2010, stratified by the presence of palpable splenomegaly. Eligible patients had 12 months or more of follow-up after diagnosis (or after detection of splenomegaly, if present) unless death occurred. Demographic and clinical characteristics, MF-related symptoms, and treatmen

SUBMITTER: Mitra D 

PROVIDER: S-EPMC3892393 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature