Enantiospecific total synthesis of N-methylwelwitindolinone D isonitrile.

ABSTRACT: The total synthesis of N-methylwelwitindolinone D isonitrile (1) has been achieved in 17 steps from a readily available carvone derivative. The route features a double C-H functionalization event involving a keto oxindole substrate to introduce the tetrahydrofuran ring of the natural product.

SUBMITTER: Styduhar ED 

PROVIDER: S-EPMC3892424 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature