Comparative analysis of proteomes and functionomes provides insights into origins of cellular diversification.

ABSTRACT: Reconstructing the evolutionary history of modern species is a difficult problem complicated by the conceptual and technical limitations of phylogenetic tree building methods. Here, we propose a comparative proteomic and functionomic inferential framework for genome evolution that allows resolving the tripartite division of cells and sketching their history. Evolutionary inferences were derived from the spread of conserved molecular features, such as molecular structures and functions, in the proteomes and functionomes of contemporary organisms. Patterns of use and reuse of these traits yielded significant insights into the origins of cellular diversification. Results uncovered an unprecedented strong evolutionary association between Bacteria and Eukarya while revealing marked evolutionary

SUBMITTER: Nasir A 

PROVIDER: S-EPMC3892558 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature