Automated annotation of developmental stages of Drosophila embryos in images containing spatial patterns of expression.

ABSTRACT:

Motivation

Drosophila melanogaster is a major model organism for investigating the function and interconnection of animal genes in the earliest stages of embryogenesis. Today, images capturing Drosophila gene expression patterns are being produced at a higher throughput than ever before. The analysis of spatial patterns of gene expression is most biologically meaningful when images from a similar time point during development are compared. Thus, the critical first step is to determine the developmental stage of an embryo. This information is also needed to observe and analyze expression changes over developmental time. Currently, developmental stages (time) of embryos in images capturing spatial expression pattern are annotated manually, which is time- and labor-intensive. Embryos

SUBMITTER: Yuan L 

PROVIDER: S-EPMC3892688 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature