Overproduction of flotillin influences cell differentiation and shape in Bacillus subtilis.

ABSTRACT:

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Bacteria organize many membrane-related signaling processes in functional microdomains that are structurally and functionally similar to the lipid rafts of eukaryotic cells. An important structural component of these microdomains is the protein flotillin, which seems to act as a chaperone in recruiting other proteins to lipid rafts to facilitate their interaction. In eukaryotic cells, the occurrence of severe diseases is often observed in combination with an overproduction of flotillin, but a functional link between these two phenomena is yet to be demonstrated. In this work, we used the bacterial model Bacillus subtilis as a tractable system to study the physiological alterations that occur in cells that overproduce flotillin. We discovered that an excess of flotillin a

SUBMITTER: Mielich-Suss B 

PROVIDER: S-EPMC3892786 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature