Endometrial profile of bazedoxifene acetate alone and in combination with conjugated equine estrogens in a primate model.

ABSTRACT:

Objective

Concerns of breast cancer risk in postmenopausal women taking combined estrogen + progestin therapy have generated interest in the use of selective estrogen receptor modulators (SERMs) as potential progestin alternatives. Endometrial proliferation and cancer risk are major concerns, however, for estrogens and certain types of SERMs when given alone. The primary aim of this study was to evaluate the endometrial profile of bazedoxifene acetate (BZA), a third-generation SERM, alone and in combination with conjugated equine estrogens (CEE) in a postmenopausal primate model.

Methods

Ninety-eight ovariectomized cynomolgus monkeys (Macaca fascicularis) were randomized to receive no hormone treatment (controls), BZA 20 mg, CEE 0.45 mg, or the combination of BZA 20 mg + CEE

SUBMITTER: Ethun KF 

PROVIDER: S-EPMC3893023 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature