Paternally expressed, imprinted insulin-like growth factor-2 in chorionic villi correlates significantly with birth weight.

ABSTRACT:

Context

Fetal growth involves highly complex molecular pathways. IGF2 is a key paternally expressed growth hormone that is critical for in utero growth in mice. Its role in human fetal growth has remained ambiguous, as it has only been studied in term tissues. Conversely the maternally expressed growth suppressor, PHLDA2, has a significant negative correlation between its term placental expression and birth weight.

Objective

The aim of this study is to address the role in early gestation of expression of IGF1, IGF2, their receptors IGF1R and IGF2R, and PHLDA2 on term birth weight.

Design

Real-time quantitative PCR was used to investigate mRNA expression of IGF1, IGF2, IGF1R, IGF2R and PHLDA2 in chorionic villus samples (CVS) (n = 260) collected at 11-13 weeks' gestati

SUBMITTER: Demetriou C 

PROVIDER: S-EPMC3893199 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature