Spatiotemporal imaging of glutamate-induced biophotonic activities and transmission in neural circuits.

ABSTRACT: The processing of neural information in neural circuits plays key roles in neural functions. Biophotons, also called ultra-weak photon emissions (UPE), may play potential roles in neural signal transmission, contributing to the understanding of the high functions of nervous system such as vision, learning and memory, cognition and consciousness. However, the experimental analysis of biophotonic activities (emissions) in neural circuits has been hampered due to technical limitations. Here by developing and optimizing an in vitro biophoton imaging method, we characterize the spatiotemporal biophotonic activities and transmission in mouse brain slices. We show that the long-lasting application of glutamate to coronal brain slices produces a gradual and significant increase of biophotonic acti

SUBMITTER: Tang R 

PROVIDER: S-EPMC3893221 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature