Effects of polymorphisms of innate immunity genes and environmental factors on the risk of noncardia gastric cancer.

ABSTRACT:

Purpose

Increasing evidence suggests that polymorphisms in innate immunity genes are associated with Helicobacter pylori-induced inflammation and may influence susceptibility in developing noncardia gastric cancer. Therefore, we investigate the effect of polymorphisms of innate immunity genes and interactions with environmental factors in the Korean population.

Materials and methods

We genotyped four polymorphisms of TLR2 (rs1898830), TLR4 (rs10983755 and rs10759932), and CD14 (rs2569190) in a case-control study of 487 noncardia gastric cancer patients and 487 sex- and age-matched healthy controls. Polytomous logistic regression models were used to detect the effects of genetic polymorphisms and environmental factors, which were stratified by the histological type of gastric

SUBMITTER: Kim J 

PROVIDER: S-EPMC3893329 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature