Increased Th1 and suppressed Th2 serum cytokine levels in subjects with diabetic coronary artery disease.

ABSTRACT:

Background

The role played by T helper cytokines under chronic, low grade inflammation as seen in type-2 Diabetes Mellitus (T2DM) and Coronary Artery Disease (CAD) co-morbidity is less well studied. In the present study, we measured the serum levels of both Th1 and Th2 cytokines and correlated it with clinical risk factors for T2DM (Insulin Resistance (IR), Glycated haemoglobin (HbA1c)) and CAD (C-Reactive Protein (CRP), Intima Media Thickness (IMT) and Augmentation index (AGI)) in T2DM subjects with/without CAD.

Methodology

The study subjects were recruited from Chennai Urban Rural Epidemiology Study (CURES). Serum cytokine profile was determined by multiplex cytokine assay in Control (n = 61), T2DM (n = 60), CAD (n = 23) and T2DM-CAD (n = 21) subjects.

Results

T2DM

SUBMITTER: Madhumitha H 

PROVIDER: S-EPMC3893369 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature