Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein.

ABSTRACT:

Background

α-Synuclein (αS) is the major component of several types of brain inclusions including Lewy bodies, a hallmark of Parkinson's disease. Aberrant aggregation of αS also is associated with cellular demise in multiple neurologic disorders collectively referred to as synucleinopathies. Recent studies demonstrate the induction of αS pathology by a single intracerebral injection of exogenous amyloidogenic αS in adult non-transgenic and transgenic mice expressing human αS. To further investigate the mechanism of pathology induction and evaluate an experimental paradigm with potential for higher throughput, we performed similar studies in neonatal mice injected with αS.

Results

In non-transgenic mice, we observed limited induction of neuronal αS inclusions predominantly 8

SUBMITTER: Sacino AN 

PROVIDER: S-EPMC3893388 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature