Impact of TCF7L2 single nucleotide polymorphisms on hydrochlorothiazide-induced diabetes.

ABSTRACT:

Objective

Thiazide diuretics have been associated with increased risk for new onset diabetes (NOD), but pharmacogenetic markers of thiazide-induced NOD are not well studied. Single nucleotide polymorphisms (SNPs) in the transcription factor 7-like 2 gene (TCF7L2) represent the strongest and most reproducible genetic associations with diabetes. We investigated the association of tag SNPs in TCF7L2 with thiazide-induced NOD.

Methods

We identified cases that developed NOD and age, sex, and race/ethnicity-matched controls from the INternational VErapamil SR-Trandolapril STudy (INVEST). INVEST compared cardiovascular outcomes between two antihypertensive treatment strategies in ethnically diverse patients with hypertension and coronary artery disease. We genotyped 101 TCF7L2 tag

SUBMITTER: Karnes JH 

PROVIDER: S-EPMC3893755 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature