Bioinformatics analysis of bacterial annexins--putative ancestral relatives of eukaryotic annexins.

ABSTRACT: Annexins are Ca(2+)-binding, membrane-interacting proteins, widespread among eukaryotes, consisting usually of four structurally similar repeated domains. It is accepted that vertebrate annexins derive from a double genome duplication event. It has been postulated that a single domain annexin, if found, might represent a molecule related to the hypothetical ancestral annexin. The recent discovery of a single-domain annexin in a bacterium, Cytophaga hutchinsonii, apparently confirmed this hypothesis. Here, we present a more complex picture. Using remote sequence similarity detection tools, a survey of bacterial genomes was performed in search of annexin-like proteins. In total, we identified about thirty annexin homologues, including single-domain and multi-domain annexins, in seventeen bac

SUBMITTER: Kodavali PK 

PROVIDER: S-EPMC3894181 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature