A bioreducible linear poly(β-amino ester) for siRNA delivery.

ABSTRACT: Described here is the synthesis and characterization of a novel, bioreducible linear poly(β-amino ester) designed to condense siRNA into nanoparticles and efficiently release it upon entering the cytoplasm. Delivery of siRNA using this polymer achieved near-complete knockdown of a fluorescent marker gene in primary human glioblastoma cells with no cytotoxicity.

SUBMITTER: Kozielski KL 

PROVIDER: S-EPMC3894248 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature