Interference with existing memories alters offline intrinsic functional brain connectivity.

ABSTRACT: The notion that already existing memories can be modified after their reactivation has received an increasing amount of experimental support, with empirical data accumulating across species and memory paradigms. However, there is no evidence for systems-level task-free intrinsic signatures of memory modification. Here, using a combination of behavioral, brain stimulation, and neuroimaging paradigms, we report that noninvasive transcranial magnetic stimulation interference with a reactivated motor memory altered offline task-free corticostriatal interregional functional connectivity, reducing it compared to stimulation in which the reactivated memory was intact. Furthermore, the modulated functional connectivity predicted offline memory modification. This reduction in functional connectivit

SUBMITTER: Censor N 

PROVIDER: S-EPMC3894578 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature