The diurnal and nocturnal effect of travoprost with sofZia on intraocular pressure and ocular perfusion pressure.

ABSTRACT:

Purpose

To determine the 24-hour effects of travoprost with sofZia on intraocular pressure (IOP) and ocular perfusion pressure as well as the endurance of IOP lowering after last dosing.

Design

Prospective, open-label study.

Methods

Forty subjects with open-angle glaucoma or ocular hypertension were admitted to our sleep laboratory for three 24-hour sessions monitoring IOP, blood pressure (BP), and heart rate. The first baseline session occurred after medication washout or immediately after enrollment for treatment-naïve patients. A second 24-hour monitoring session was performed after 4 weeks of once-nightly treatment of travoprost with sofZia. The medication was then discontinued and a third 24-hour session was completed 60-84 hours after the last dose taken. IOP me

SUBMITTER: Seibold LK 

PROVIDER: S-EPMC3894832 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature