Whole-body imaging of high-dose ionizing irradiation-induced tissue injuries using 99mTc-duramycin.

ABSTRACT:

Unlabelled

High-dose ionizing irradiation can cause extensive injuries in susceptible tissues. A noninvasive imaging technique that detects a surrogate marker of apoptosis may help characterize the dynamics of radiation-induced tissue damage. The goal of this study was to prove the concept of imaging the temporal and spatial distribution of damage in susceptible tissues after high-dose radiation exposure, using (99m)Tc-duramycin as a phosphatidylethanolamine-binding radiopharmaceutical.

Methods

Rats were subjected to 15 Gy of total-body irradiation with x-rays. Planar whole-body (99m)Tc-duramycin scanning (n = 4 per time point) was conducted at 24, 48, and 72 h using a clinical γ-camera. On the basis of findings from planar imaging, preclinical SPECT data were acquired on co

SUBMITTER: Johnson SE 

PROVIDER: S-EPMC3894925 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature