A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication.

ABSTRACT: Through screening by NMR spectroscopy, we discovered a novel scaffold (DPQ: 6,7-dimethoxy-2-(1-piperazinyl)-4-quinazolinamine) that binds specifically to the influenza A virus RNA promoter. The solution structure of the RNA-DPQ complex reported here demonstrates that the internal loop is the binding site of DPQ. The scaffold exhibits antiviral activity against influenza viruses.

SUBMITTER: Lee MK 

PROVIDER: S-EPMC3894927 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature